The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease

Diagn Microbiol Infect Dis. 2017 Jan;87(1):22-24. doi: 10.1016/j.diagmicrobio.2016.10.015. Epub 2016 Oct 11.

Abstract

Bartonella henselae strains genetically differ among nations. The utility of Japanese-specific YH-01 strain was investigated in developing indirect fluorescence antibody assay (IFA) for IgM in comparison with conventional IFA employing Houston-1 strain by testing 100 Japanese patients suspected of cat scratch disease. The country-specific IFA greatly improved the accuracy of diagnosis.

Keywords: Bartonella henselae; Cat scratch disease; IFA; IgM; Multispacer typing.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial / immunology*
  • Bartonella henselae / immunology*
  • Cat-Scratch Disease / diagnosis*
  • Cats
  • Child, Preschool
  • Diagnostic Tests, Routine / methods*
  • Female
  • Fluorescent Antibody Technique, Indirect / methods*
  • Humans
  • Immunoglobulin M / blood*
  • Japan
  • Male
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Immunoglobulin M