Abstract
Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
MeSH terms
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Biological Products / chemistry*
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Crystallography, X-Ray
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Fermentation
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Histone Deacetylases / chemistry
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Histone Deacetylases / drug effects*
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Lactams / chemistry
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Lactams / isolation & purification*
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Lactams / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Monascus / chemistry*
Substances
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Biological Products
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Enzyme Inhibitors
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Lactams
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monascustin
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red yeast rice
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Histone Deacetylases