Cutaneous Exophiala oligosperma Infection in a Patient with Bullous Pemphigoid with a Review of the Literature

Mycopathologia. 2017 Jun;182(5-6):539-547. doi: 10.1007/s11046-016-0104-6. Epub 2016 Dec 26.

Abstract

Phaeohyphomycosis is an infection caused by a heterogeneous group of melanized fungi. Human infections due to members of genus Exophiala are rare but may occur at any part of the body. We herein report a case of an 85-year-old male with a history of bullous pemphigoid who presented with a chronic, non-healing wound on his right dorsal hand for a month. Direct microscopy of a pus sample from the base of the ulcer revealed strands of pigmented, moniliform hyphae. The isolate was identified as E. oligosperma based on morphological characters and sequencing of the rDNA internal transcribed spacers (ITS) and partial beta-tubulin gene. The patient received a three-month course of oral itraconazole with no recurrence.

Keywords: Bullous pemphigoid; Exophiala oligosperma; Fungal infection; Phaeohyphomycosis; Skin.

Publication types

  • Review

MeSH terms

  • Aged, 80 and over
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Exophiala / isolation & purification*
  • Hand / pathology
  • Humans
  • Male
  • Microbiological Techniques
  • Microscopy
  • Pemphigoid, Bullous / etiology*
  • Pemphigoid, Bullous / pathology*
  • Phaeohyphomycosis / diagnosis*
  • Phaeohyphomycosis / pathology*
  • Phylogeny
  • Sequence Analysis, DNA
  • Tubulin / genetics

Substances

  • DNA, Fungal
  • DNA, Ribosomal Spacer
  • Tubulin