Single cardiac cycle three-dimensional intracoronary optical coherence tomography

Tae Shik Kim; Hyun-Sang Park; Sun-Joo Jang; Joon Woo Song; Han Saem Cho; Sunwon Kim; Brett E Bouma; Jin Won Kim; Wang-Yuhl Oh

doi:10.1364/BOE.7.004847

Single cardiac cycle three-dimensional intracoronary optical coherence tomography

Biomed Opt Express. 2016 Nov 1;7(12):4847-4858. doi: 10.1364/BOE.7.004847. eCollection 2016 Dec 1.

Authors

Tae Shik Kim¹, Hyun-Sang Park¹, Sun-Joo Jang², Joon Woo Song³, Han Saem Cho⁴, Sunwon Kim⁵, Brett E Bouma⁶, Jin Won Kim³, Wang-Yuhl Oh⁷

Affiliations

¹ Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; These authors contributed equally to this work.
² KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; Currently at Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; These authors contributed equally to this work.
³ Cardiovascular Center, Korea University Guro Hospital, 80 Guro-dong, Guro-gu, Seoul, South Korea.
⁴ Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; Currently at Center for Medical Metrology, Korea Research Institute of Standards and Science, 267 Gajeong-ro, Yuseong-gu, Daejeon, South Korea.
⁵ Currently at Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
⁶ Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
⁷ Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea.

Abstract

While high-speed intracoronary optical coherence tomography (OCT) provides three-dimensional (3D) visualization of coronary arteries in vivo, imaging speeds remain insufficient to avoid motion artifacts induced by heartbeat, limiting the clinical utility of OCT. In this paper, we demonstrate development of a high-speed intracoronary OCT system (frame rate: 500 frames/s, pullback speed: 100 mm/s) along with prospective electrocardiogram (ECG) triggering technology, which enabled volumetric imaging of long coronary segments within a single cardiac cycle (70 mm pullback in 0.7 s) with minimal cardiac motion artifact. This technology permitted detailed visualization of 3D architecture of the coronary arterial wall of a swine in vivo and fine structure of the implanted stent.

Keywords: (170.2150) Endoscopic imaging; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography.

Grants and funding

P41 EB015903/EB/NIBIB NIH HHS/United States