Lipid Therapy for Intoxications

Joris Henricus Robben; Marieke Annet Dijkman

doi:10.1016/j.cvsm.2016.10.018

Lipid Therapy for Intoxications

Vet Clin North Am Small Anim Pract. 2017 Mar;47(2):435-450. doi: 10.1016/j.cvsm.2016.10.018. Epub 2016 Dec 21.

Authors

Joris Henricus Robben¹, Marieke Annet Dijkman²

Affiliations

¹ Intensive Care Unit, Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.154, Utrecht NL-3584 CM, The Netherlands. Electronic address: j.h.robben@uu.nl.
² Dutch Poisons Information Center, Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

PMID: 28012788
DOI: 10.1016/j.cvsm.2016.10.018

Abstract

This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.

Keywords: Emulsion; Fat; ILE; Intralipid; Lipid; Lipid resuscitation therapy; Poisoning; Toxin.

Publication types

Review

MeSH terms

Administration, Intravenous / methods
Administration, Intravenous / veterinary
Animals
Cats
Dogs
Fat Emulsions, Intravenous / therapeutic use*
Humans
Ivermectin / adverse effects
Poisoning / therapy
Poisoning / veterinary*

Substances

Fat Emulsions, Intravenous
Ivermectin