Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?

Clin Imaging. 2017 Mar-Apr:42:147-151. doi: 10.1016/j.clinimag.2016.11.015. Epub 2016 Nov 30.

Abstract

Introduction: We studied computed tomography (CT) features associated with BRAF mutated lung cancer.

Materials and methods: CT features of BRAF mutated lung cancers were compared to stage matched lesions without BRAF mutation.

Results: 47 (25%) patients with BRAF mutation and 141 (75%) without BRAF mutation were included. BRAF lesions were most frequently solid 37 (84%), spiculated 22 (50%), and peripheral 37 (84%). No feature of the primary tumor was significantly different between BRAF and non-BRAF groups. BRAF patients were more likely than KRAS patients to have pleural metastases [5 (11%) vs 0 (0%), p=0.045].

Conclusion: No feature of the primary tumor differentiates BRAF lesions from non-BRAF lesions.

Keywords: BRAF mutation; Computed tomography; Lung carcinoma; Radiogenomics.

MeSH terms

  • Adenocarcinoma / diagnostic imaging*
  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Mutation*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Tomography, X-Ray Computed

Substances

  • Proto-Oncogene Proteins B-raf