Triterpene saponins and megastigmane glucosides from Camellia bugiamapensis

Bioorg Med Chem Lett. 2017 Feb 1;27(3):557-561. doi: 10.1016/j.bmcl.2016.12.020. Epub 2016 Dec 8.

Abstract

Two new triterpene saponins, camelliosides I and J (1 and 2), two new megastigmane glycosides, camellistigosides A and B (3 and 4), and two known megastigmane glycosides, icariside B1 (5) and (6S,9R)-roseoside (6), were isolated from a methanol extract of the Camellia bugiamapensis leaves using various chromatographic separation techniques. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, CD, 1D and 2D NMR. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were evaluated. This is the first report of the chemical constituents and biological activity of C. bugiamapensis.

Keywords: Camellia bugiamapensis; NO production; Theaceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Camellia / chemistry*
  • Cyclohexanones / chemistry
  • Cyclohexanones / isolation & purification
  • Cyclohexanones / pharmacology*
  • Dose-Response Relationship, Drug
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Humans
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors
  • Nitric Oxide / biosynthesis
  • Norisoprenoids / chemistry
  • Norisoprenoids / isolation & purification
  • Norisoprenoids / pharmacology*
  • RAW 264.7 Cells
  • Saponins / chemistry
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*

Substances

  • Cyclohexanones
  • Glucosides
  • Lipopolysaccharides
  • Norisoprenoids
  • Saponins
  • Triterpenes
  • megastigmane
  • Nitric Oxide