Use of Cellular Decapping Activators by Positive-Strand RNA Viruses

Viruses. 2016 Dec 21;8(12):340. doi: 10.3390/v8120340.

Abstract

Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5'-3' mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus.

Keywords: mRNA decay; positive strand RNA viruses; virus–host interactions.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bromovirus / physiology*
  • Endoribonucleases / metabolism*
  • Hepacivirus / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Nodaviridae / physiology*
  • Protein Biosynthesis*
  • RNA Stability
  • Virus Replication*

Substances

  • mRNA decapping enzymes
  • Endoribonucleases