Gradient and Patterned Protein Films Stabilized via Nanoimprint Lithography for Engineered Interactions with Cells

ACS Appl Mater Interfaces. 2017 Jan 11;9(1):42-46. doi: 10.1021/acsami.6b13815. Epub 2016 Dec 28.

Abstract

Protein-based biomaterials provide versatile scaffolds for generating functional surfaces for biomedical applications. However, tailoring the functional and biological properties of protein films remains a challenge. Here, we describe a high-throughput method to designing stable, functional biomaterials by combining inkjet deposition of protein inks with a nanoimprint lithography based methodology. The translation of the intrinsically charged proteins into functional materials properties was demonstrated through controlled cellular adhesion. This modular strategy offers a rapid method to produce customizable biomaterials.

Keywords: biomaterial; cell patterning; inkjet printing; nanoimprint lithography; thin films.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials
  • Cell Adhesion
  • Humans
  • Nanostructures*
  • Printing
  • Proteins
  • Surface Properties

Substances

  • Biocompatible Materials
  • Proteins