Aptamer-tagged DNA origami for spatially addressable detection of aflatoxin B1

Zhisong Lu; Ying Wang; Dan Xu; Lei Pang

doi:10.1039/c6cc08831g

Aptamer-tagged DNA origami for spatially addressable detection of aflatoxin B1

Chem Commun (Camb). 2017 Jan 10;53(5):941-944. doi: 10.1039/c6cc08831g.

Authors

Zhisong Lu¹, Ying Wang¹, Dan Xu², Lei Pang¹

Affiliations

¹ Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, 1 Tiansheng Road, Chongqing 400715, P. R. China and Chongqing Key Laboratory for Advanced Materials & Technologies of Clean Energies, 1 Tiansheng Road, Chongqing 400715, P. R. China. zslu@swu.edu.cn.
² Department of Gastroenterology, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Shengli Street Jiang'an District No. 26, Wuhan 430014, P. R. China and Key Laboratory for Molecular Diagnosis of Hubei Province, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Shengli Street Jiang'an District No. 26, Wuhan 430014, P. R. China. drxu0624@gmail.com.

PMID: 28008436
DOI: 10.1039/c6cc08831g

Abstract

A DNA origami-based platform for detecting aflatoxin B1 has been constructed with the assistance of aptamer probes and its complementary ssDNA-modified gold nanoparticles. This work may open new horizons for the application of DNA origami in the detection of a variety of small molecules.

MeSH terms

Aflatoxin B1 / analysis*
Aptamers, Nucleotide / chemistry*
DNA / chemistry*
Gold / chemistry
Nanostructures / chemistry*

Substances

Aptamers, Nucleotide
Gold
DNA
Aflatoxin B1