Cross-Reactivity Between Heparin and Danaparoid Antibodies in Cardiac Surgery

Thibault Ronchard; Erwan Salaun; Alexis Theron; Dominique Grisoli; Nicolas Jaussaud; Frédéric Collart; Gilbert Habib; Laurence Camoin-Jau

doi:10.1016/j.athoracsur.2016.06.068

Cross-Reactivity Between Heparin and Danaparoid Antibodies in Cardiac Surgery

Ann Thorac Surg. 2017 Jan;103(1):e9-e10. doi: 10.1016/j.athoracsur.2016.06.068.

Authors

Thibault Ronchard¹, Erwan Salaun², Alexis Theron¹, Dominique Grisoli¹, Nicolas Jaussaud¹, Frédéric Collart¹, Gilbert Habib³, Laurence Camoin-Jau⁴

Affiliations

¹ Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
² Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France; Service Cardiologie, C.H.U. La Timone, APHM, Marseille, France.
³ Service Cardiologie, C.H.U. La Timone, APHM, Marseille, France; Laboratoire d'Hématologie, C.H.U. La Timone, APHM, Marseille, France.
⁴ Aix-Marseille Université, URMITE, UM63, CNRS 7278, Inserm U1095, Faculté de Médecine, Marseille, France; Laboratoire d'Hématologie, C.H.U. La Timone, APHM, Marseille, France. Electronic address: lcamoin@ap-hm.fr.

PMID: 28007287
DOI: 10.1016/j.athoracsur.2016.06.068

Abstract

Management of heparin-induced thrombocytopenia (HIT) entails cessation of heparin and initiation of a nonheparin parenteral anticoagulant such as danaparoid. Danaparoid cross-reactivity with HIT antibodies is an uncommon complication of treatment of HIT. We report the case of confirmed HIT and in vivo cross-reactivity with danaparoid, complicating severe sepsis due to an infectious endocarditis treated by cardiac surgery.

Publication types

Case Reports

MeSH terms

Anticoagulants / immunology
Anticoagulants / therapeutic use
Cardiac Surgical Procedures*
Chondroitin Sulfates / immunology*
Chondroitin Sulfates / therapeutic use
Cross Reactions
Dermatan Sulfate / immunology*
Dermatan Sulfate / therapeutic use
Heart Valve Diseases / surgery*
Heparin / adverse effects
Heparin / immunology*
Heparitin Sulfate / immunology*
Heparitin Sulfate / therapeutic use
Humans
Male
Middle Aged
Thrombocytopenia / complications*
Thrombocytopenia / immunology

Substances

Anticoagulants
Dermatan Sulfate
Heparin
Chondroitin Sulfates
Heparitin Sulfate
danaparoid