Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise

Appl Physiol Nutr Metab. 2017 Jan;42(1):89-92. doi: 10.1139/apnm-2016-0224. Epub 2016 Oct 18.

Abstract

We investigated the acute myogenic response to resistance exercise with and without blood-flow restriction (BFR). Six men and women (age, 22 ± 1 years) performed unilateral knee extensions at 40% of 1-repetition maximum with or without (CNTRL) BFR applied via pressure cuff inflated to 220 mm Hg. Muscle biopsies were collected at 4 h and 24 h postexercise. Addition of BFR increased myoD and c-Met messenger RNA expression relative to CNTRL. Expression of hepatocyte growth factor protein was significantly higher following CNTRL.

Keywords: KAATSU; blood flow restriction; exercice contre résistance; facteur de croissance des hépatocytes; hepatocyte growth factor; muscle squelettique; myogenesis; myogenèse; resistance exercise; restriction du débit sanguin; skeletal muscle.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / metabolism
  • Biopsy, Needle
  • Constriction
  • Cross-Over Studies
  • Female
  • Gene Expression Regulation
  • Hepatocyte Growth Factor / genetics
  • Hepatocyte Growth Factor / metabolism*
  • Humans
  • Male
  • Muscle Development*
  • MyoD Protein / genetics
  • MyoD Protein / metabolism*
  • Proto-Oncogene Proteins c-met / genetics
  • Proto-Oncogene Proteins c-met / metabolism*
  • Quadriceps Muscle / growth & development
  • Quadriceps Muscle / metabolism*
  • RNA, Messenger / metabolism
  • Resistance Training / methods*
  • Time Factors
  • Up-Regulation*
  • Young Adult

Substances

  • Biomarkers
  • HGF protein, human
  • MyoD Protein
  • RNA, Messenger
  • Hepatocyte Growth Factor
  • MET protein, human
  • Proto-Oncogene Proteins c-met