Smart Microbubble Eluting Theranostic Stent for Noninvasive Ultrasound Imaging and Prevention of Restenosis

Do Hee Keum; Jong Hwan Mun; Byung Woo Hwang; Jeesu Kim; Heejaung Kim; Woori Jo; Dong-Heon Ha; Dong-Woo Cho; Chulhong Kim; Sei Kwang Hahn

doi:10.1002/smll.201602925

Smart Microbubble Eluting Theranostic Stent for Noninvasive Ultrasound Imaging and Prevention of Restenosis

Small. 2017 Mar;13(10). doi: 10.1002/smll.201602925. Epub 2016 Dec 21.

Authors

Affiliations

¹ Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, 790-784, South Korea.
² Department of Creative IT Engineering and Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, 790-784, South Korea.
³ Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, 80 Cheombok-ro, Dong-gu, Daegu, 701-310, South Korea.
⁴ Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, 790-784, South Korea.

PMID: 28001324
DOI: 10.1002/smll.201602925

Abstract

A pH-responsive microbubble-eluting theranostic stent is developed for real-time ultrasound imaging of stent implanted blood vessels and dissolution of fat-rich plaques to prevent the blocking of blood vessels in rats. This smart theranostic stent can be effectively applied to facilitate noninvasive monitoring and prevent restenosis after stent implantation.

Keywords: calcium carbonate; microbubbles; restenosis; stents; ultrasound imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Coronary Restenosis / diagnostic imaging*
Coronary Restenosis / prevention & control*
Female
Male
Mice, Inbred C57BL
Microbubbles
Rats
Stents*
Theranostic Nanomedicine / methods*
Treatment Outcome
Ultrasonography / methods*