Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation

Heather M Snyder; Tim Ahles; Stuart Calderwood; Maria C Carrillo; Honglei Chen; Chung-Chou H Chang; Suzanne Craft; Philip De Jager; Jane A Driver; Howard Fillit; David Knopman; Michael Lotze; Mary C Tierney; Suzana Petanceska; Andrew Saykin; Sudha Seshadri; Diana Shineman; Mary Ganguli

doi:10.1016/j.jalz.2016.11.002

Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies: A convening of the Alzheimer's Association & Alzheimer's Drug Discovery Foundation

Alzheimers Dement. 2017 Mar;13(3):267-273. doi: 10.1016/j.jalz.2016.11.002. Epub 2016 Dec 18.

Authors

Heather M Snyder¹, Tim Ahles², Stuart Calderwood³, Maria C Carrillo⁴, Honglei Chen⁵, Chung-Chou H Chang⁶, Suzanne Craft⁷, Philip De Jager⁸, Jane A Driver⁹, Howard Fillit¹⁰, David Knopman¹¹, Michael Lotze¹², Mary C Tierney¹³, Suzana Petanceska¹⁴, Andrew Saykin¹⁵, Sudha Seshadri¹⁶, Diana Shineman¹⁰, Mary Ganguli¹⁷

Affiliations

¹ Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
² Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³ Radiation Oncology, Harvard University Medical School, Boston, MA, USA.
⁴ Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
⁵ Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
⁶ Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Biostatistics, University of Pittsburgh Medical School, Pittsburgh, PA, USA; Clinical and Translational Science, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
⁷ Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University of Medicine, Winston-Salem, NC, USA.
⁸ Geriatric Research Education and Clinical Center, VA Boston HealthCare System, Boston, MA, USA.
⁹ Division of Aging, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard University Medical School, Boston, MA, USA.
¹⁰ Scientific Affairs, Alzheimer's Drug Discovery Foundation, New York, NY, USA.
¹¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
¹² Departments of Surgery, Immunology and Bioengineering, University of Pittsburgh Medical School, Pittsburgh, PA, USA.
¹³ Department of Family and Community Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada.
¹⁴ Division of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
¹⁵ Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA.
¹⁶ Division of Neurology, Boston University Medical School, Boston, MA, USA.
¹⁷ Professor of Psychiatry, Neurology, and Epidemiology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA.

Abstract

Recent population studies suggest an intriguing inverse relationship between several types of cancer and neurodegenerative diseases, including Alzheimer's disease. Understanding the intersection of the underlying biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates. The Alzheimer's Association and the Alzheimer's Drug Discovery Foundation convened a one-day workshop to delve into this discussion. Workshop participants outlined research focus areas, potential collaborations, and partnerships for future action.

Keywords: Alzheimer's disease; Biological mechanisms; Cancer; Epidemiology; Genetics; Oncology; Repurpose therapy.

Publication types

Review

MeSH terms

Alzheimer Disease* / complications
Alzheimer Disease* / drug therapy
Alzheimer Disease* / epidemiology
Antineoplastic Agents / therapeutic use*
Dementia / complications*
Dementia / epidemiology
Drug Discovery
Humans
Neoplasms* / epidemiology
Neoplasms* / etiology
Neoplasms* / therapy

Substances

Antineoplastic Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding