Robo-Enabled Tumor Cell Extrusion

Helena E Richardson; Marta Portela

doi:10.1016/j.devcel.2016.12.008

Robo-Enabled Tumor Cell Extrusion

Dev Cell. 2016 Dec 19;39(6):629-631. doi: 10.1016/j.devcel.2016.12.008.

Authors

Helena E Richardson¹, Marta Portela²

Affiliations

¹ Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: h.richardson@latrobe.edu.au.
² Department of Molecular, Cellular, and Developmental Neurobiology, Cajal Institute (CSIC), Avenida Doctor Arce, 37, Madrid 28002, Spain.

PMID: 27997819
DOI: 10.1016/j.devcel.2016.12.008

Abstract

How aberrant cells are removed from a tissue to prevent tumor formation is a key question in cancer biology. Reporting in this issue of Developmental Cell, Vaughen and Igaki (2016) show that a pathway with an important role in neural guidance also directs extrusion of tumor cells from epithelial tissues.

Publication types

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MeSH terms

Epithelium / metabolism
Humans
Nerve Tissue Proteins / metabolism*
Receptors, Immunologic / metabolism*
Signal Transduction

Substances

Nerve Tissue Proteins
Receptors, Immunologic