Hox Service Warranty Extends to Adult Bone Repair

Andrew J Saurin; Marie-Claire Delfini; Yacine Graba

doi:10.1016/j.devcel.2016.12.007

Hox Service Warranty Extends to Adult Bone Repair

Dev Cell. 2016 Dec 19;39(6):627-629. doi: 10.1016/j.devcel.2016.12.007.

Authors

Andrew J Saurin¹, Marie-Claire Delfini¹, Yacine Graba²

Affiliations

¹ Aix-Marseille Université, CNRS, IBDM, UMR7288, case 907, 13288 Marseille Cedex 09, France.
² Aix-Marseille Université, CNRS, IBDM, UMR7288, case 907, 13288 Marseille Cedex 09, France. Electronic address: yacine.graba@univ-amu.fr.

PMID: 27997818
DOI: 10.1016/j.devcel.2016.12.007

Abstract

Hox genes are key developmental regulators. In this issue of Developmental Cell, Rux et al. (2016) uncover an adult role for Hox11 genes in regionalized bone repair. This function relies on Hox activity in bone marrow multipotent mesenchymal stem progenitor cells, which promotes skeletal cell differentiation.

Publication types

Comment

MeSH terms

Adult
Bone Marrow Cells / cytology
Cell Differentiation / genetics*
Genes, Homeobox
Homeodomain Proteins / genetics*
Humans
Multipotent Stem Cells

Substances

Homeodomain Proteins