Increasing variability of climate-related factors, especially precipitation and temperature, poses special risks to on-site wastewater treatment systems (OWTS), which depend on subsurface saturation conditions for treatment and dispersion of wastewater. We assess OWTS fragility - the degree to which a system loses functionality - as a step to characterizing the resilience of residential wastewater treatment systems. We used the frequency and indexed severity of OWTS failures and resulting repairs to quantify fragility as a function of hydroclimate variables, including precipitation, temperature and stream flow. The frequency of each category of repair (minor, moderate and major) for 225 OWTS obtained from Boulder County public health records was modeled as a function of climate factors using a generalized linear model with a Poisson distribution link function. The results show that prolonged precipitation patterns, with monthly rainfall >10.16 cm, influence OWTS fragility, and complete loss of OWTS functionality, requiring replacement, is impacted by high temperatures, frequency of wetter-than-normal months, and the magnitude of peak stream flow in the watershed. Weather-related covariates explained 70% of the variability in OWTS major repair data between 1979 and 2006. These results indicate that fragility arising from climate factors, and associated costs to owners, environmental and health impacts, should be considered in planning, design and operation of OWTS.