Host immunity to Mycobacterium tuberculosis and risk of tuberculosis: A longitudinal study among Greenlanders

Vaccine. 2016 Nov 21;34(48):5975-5983. doi: 10.1016/j.vaccine.2016.09.047. Epub 2016 Oct 27.

Abstract

Background: Human immune responses to latent Mycobacterium tuberculosis (Mtb) infection (LTBI) may enable individuals to control Mtb infection and halt progression to tuberculosis (TB), a hypothesis applied in several novel TB vaccines. We aimed to evaluate whether immune responses to selected LTBI antigens were associated with subsequent reduced risk of progression to TB.

Methods: We conducted a population-based cohort study in East Greenland (2012-2014) including individuals aged 5-31years. A personal identifier allowed follow-up in national registers including the TB notification register. Mtb infection was defined by a positive Quantiferon test. Immune responses to LTBI antigens were assessed by whole blood antigen stimulation and interferon gamma measurement.

Results: Among 978 participants, 67 previously had TB. LTBI antigen (Rv1284, Rv2659, Rv2660c) immune response prevalence was 18%, 50%, 2% among Mtb-infected and 7%, 40%, 4% among non-infected (Quantiferon negative) participants. Among 911 participants without prior notified TB, 31 were notified with TB during study follow-up. Immune responses to LTBI antigens were not associated with reduced risk of subsequent TB; Rv1284 HR 0.92 (95%CI 0.28-3.04), Rv2659 HR 1.05 (95%CI 0.51-2.13), Rv2660c HR 3.06 (95%CI 0.70-13.37).

Conclusion: In this large population-based study, human immune responses to selected LTBI antigens were not found to be strongly associated with reduced risk of subsequent TB.

Keywords: Antigens; Epidemiology; Immunity; Tuberculosis; Vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens, Bacterial / immunology*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Disease Progression
  • Epidemiologic Studies
  • Female
  • Greenland / epidemiology
  • Humans
  • Immunity, Cellular*
  • Interferon-gamma / biosynthesis
  • Latent Tuberculosis / epidemiology
  • Latent Tuberculosis / immunology*
  • Longitudinal Studies
  • Male
  • Mycobacterium tuberculosis / immunology*
  • Risk Factors
  • Tuberculosis / epidemiology
  • Tuberculosis / immunology*
  • Tuberculosis Vaccines / administration & dosage
  • Tuberculosis Vaccines / immunology
  • Young Adult

Substances

  • Antigens, Bacterial
  • Tuberculosis Vaccines
  • Interferon-gamma