Chiral Lithium Amides: Tuning Asymmetric Synthesis on the Basis of Structural Parameters

Abstract

An overview on the structural arrangements adopted by Chiral Lithium Amides (CLAs), alone or in mixed complexes, is presented. These species are important reagents for asymmetric synthesis and understanding their organization is essential to improve their design and the reaction conditions.

Keywords: Chiral lithium amide; NMR; Structure/Reactivity relationship; aggregation; crystallography.