Epithelial ovarian cancer inherent resistance: May the pleiotropic interaction between reduced immunosurveillance and drug-resistant cells play a key role?

Antonio Simone Laganà; Vincenza Sofo; Salvatore Giovanni Vitale; Onofrio Triolo

doi:10.1016/j.gore.2016.09.004

Epithelial ovarian cancer inherent resistance: May the pleiotropic interaction between reduced immunosurveillance and drug-resistant cells play a key role?

Gynecol Oncol Rep. 2016 Sep 19:18:57-58. doi: 10.1016/j.gore.2016.09.004. eCollection 2016 Nov.

Authors

Antonio Simone Laganà¹, Vincenza Sofo², Salvatore Giovanni Vitale¹, Onofrio Triolo¹

Affiliations

¹ Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
² Department of Biomedical Sciences, Dentistry and Morphological and Functional Imaging, University of Messina, Messina, Italy.

Abstract

•Cancer cells may have inherent chemoresistance which allows an indefinite expansion.•Transformed ovarian epithelial cells may undergo an immunoediting process.•Immunoedited ovarian cancer drug-resistant cells escape first-line chemotherapy.