EGF-R Protein Expression and Gene Amplification do not Correlate in Pancreas Cancer

Gian Luca Baiocchi; Vincenzo Villanacci; Elisa Rossi; Daniela Zanotti; Stefano Maria Giulini

doi:10.4021/gr2008.11.1248

EGF-R Protein Expression and Gene Amplification do not Correlate in Pancreas Cancer

Gastroenterology Res. 2008 Dec;1(1):55-56. doi: 10.4021/gr2008.11.1248. Epub 2008 Nov 20.

Authors

Gian Luca Baiocchi¹, Vincenzo Villanacci², Elisa Rossi², Daniela Zanotti¹, Stefano Maria Giulini¹

Affiliations

¹ Surgical Clinic, Department of Medical and Surgical Sciences, Brescia University, III Chirurgia, Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.
² Department of Pathology, Brescia University.

Abstract

In a series of 13 pancreas cancer specimens, EGF-R was evaluated by means of both immunohistochemistry (IHC) for protein expression and FISH for genetic amplification. The results were discording in 7 cases (IHC positive, FISH negative), while in the remaining 6 cases both IHC and FISH were negative. The possible clinical implications of these results are discussed.

Keywords: EGF-R; FISH; cancer; immunohistochemistry; pancreas.