Avoiding Pitfalls in the Interpretation of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging

Semin Ultrasound CT MR. 2016 Dec;37(6):561-572. doi: 10.1053/j.sult.2016.08.002. Epub 2016 Aug 12.

Abstract

Gadoxetic acid is extensively used in the following 3 main clinical situations: characterization of small nodules in patients with cirrhosis, preoperative staging of liver metastases, and characterization of incidentally discovered focal liver lesions. Owing to the rapid entry of gadoxetic acid into hepatocytes, the traditional features of liver tumors are modified on magnetic resonance (MR) imaging, especially during delayed phase sequences. Thus, although the added value of gadoxetic acid for the detection and characterization of focal liver lesions is now clear, its unique pharmacokinetics as well as the presence of mimicking and atypical lesions may lead to misdiagnoses. The goal of this article is to illustrate common and uncommon pitfalls associated with the use of gadoxetic acid-enhanced MR imaging. Moreover, additional MR imaging features that can help establish a correct diagnosis are described.

Publication types

  • Review

MeSH terms

  • Contrast Media
  • Gadolinium DTPA*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Liver Diseases / diagnostic imaging*
  • Magnetic Resonance Imaging / methods*
  • Sensitivity and Specificity

Substances

  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA