Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?

CPT Pharmacometrics Syst Pharmacol. 2017 Apr;6(4):226. doi: 10.1002/psp4.12164. Epub 2017 Apr 11.

Authors

M Tod^{1

2}, S Goutelle^{1

3}, L Bourguignon^{1

3}, N Bleyzac^{2

4}

Affiliations

¹ Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France.
² EMR3738, Université Claude Bernard Lyon 1, Lyon, France.
³ UMR5758, Université Claude Bernard Lyon 1, Lyon, France.
⁴ Institut d'Hémato-Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.

No abstract available

Publication types

Letter
Comment

MeSH terms

Cytochrome P-450 CYP3A Inhibitors*
Drug Interactions

Substances

Cytochrome P-450 CYP3A Inhibitors