A Generalizable Strategy for the 3D Bioprinting of Hydrogels from Nonviscous Photo-crosslinkable Inks

Liliang Ouyang; Christopher B Highley; Wei Sun; Jason A Burdick

doi:10.1002/adma.201604983

A Generalizable Strategy for the 3D Bioprinting of Hydrogels from Nonviscous Photo-crosslinkable Inks

Adv Mater. 2017 Feb;29(8). doi: 10.1002/adma.201604983. Epub 2016 Dec 16.

Authors

Liliang Ouyang^{1

2}, Christopher B Highley¹, Wei Sun², Jason A Burdick¹

Affiliations

¹ Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA, 19104, USA.
² Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.

PMID: 27982464
DOI: 10.1002/adma.201604983

Abstract

An in situ crosslinking strategy is used for 3D bioprinting of nonviscous photo-crosslinkable hydrogels. This method can be generalized to various photo-crosslinkable formulations, maintaining high embedded cell viability and tunable cell behavior. Heterogeneous and hollow filaments can be printed using this strategy, allowing fabrication of complex engineered cell-laden constructs.

Keywords: 3D printing; biomaterials; bioprinting; hydrogels; photo-crosslinking.