Diagnosis of Cushing's disease in a patient with consistently normal urinary free cortisol levels: a case report

Kelley J Moloney; Jennifer U Mercado; William H Ludlam; Frances E Broyles

doi:10.1002/ccr3.647

Diagnosis of Cushing's disease in a patient with consistently normal urinary free cortisol levels: a case report

Clin Case Rep. 2016 Nov 9;4(12):1181-1183. doi: 10.1002/ccr3.647. eCollection 2016 Dec.

Authors

Kelley J Moloney¹, Jennifer U Mercado¹, William H Ludlam², Frances E Broyles¹

Affiliations

¹ Seattle Pituitary Center Swedish Neuroscience Institute Seattle Washington USA.
² Novartis Pharmaceuticals Corporation East Hanover New Jersey USA.

Abstract

The urinary free cortisol (UFC) test is widely used for the screening of Cushing's syndrome. This case study illustrates the potential failure of the UFC test to correctly diagnose Cushing's disease (CD), indicating that the use of other complementary tests may be necessary to diagnose this disease in some cases.

Keywords: Biological markers/urine; Cushing's syndrome; diagnosis; pituitary ACTH hypersecretion; urinary free cortisol.

Publication types

Case Reports