Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Tetsuya Suzuki; Hiroyuki Kamiya

doi:10.1186/s41021-016-0051-y

Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Genes Environ. 2016 Dec 1:39:2. doi: 10.1186/s41021-016-0051-y. eCollection 2017.

Authors

Tetsuya Suzuki¹, Hiroyuki Kamiya¹

Affiliation

¹ Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 Japan.

Abstract

Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major products is 8-hydroxyguanine (8-oxo-7,8-dihydroguanine). The mutagenic potentials of this oxidized base have been examined in various experimental systems. In this review, we summarize the mutagenicity of the base in mammalian cells. We also describe the effects of specialized DNA polymerases, DNA repair proteins, and nucleotide pool sanitization enzymes.

Keywords: 8-Hydroxyguanine; 8-Oxo-7,8-dihydroguanine; DNA repair protein; Nucleotide pool sanitization enzyme; Specialized DNA polymerase.

Publication types

Review