The SAMP8 mouse for investigating memory and the role of insulin in the brain

Exp Gerontol. 2017 Aug:94:64-68. doi: 10.1016/j.exger.2016.12.009. Epub 2016 Dec 12.

Abstract

SAMP8 mice exhibit changes that commonly occur with normal aging late in life, but do so at a much earlier age. These changes include impairments in learning and memory as early as 8months of age and so the SAMP8 is a useful model to investigate those age-related brain changes that may affect cognition. As brain insulin signaling and memory decline with aging, the SAMP8 model is useful for investigating these changes and interventions that might prevent the decline. This review will summarize the SAMP8 mouse model, highlight changes in brain insulin signaling and its role in memory, and discuss intranasal insulin delivery in investigating effects on insulin metabolism and memory in the SAMP8 mice.

Keywords: Insulin; Memory; SAMP8.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Behavior, Animal* / drug effects
  • Brain / drug effects
  • Brain / metabolism*
  • Brain / physiopathology
  • Cognition Disorders / drug therapy
  • Cognition Disorders / genetics
  • Cognition Disorders / metabolism*
  • Cognition Disorders / psychology
  • Cognitive Aging*
  • Disease Models, Animal
  • Genotype
  • Humans
  • Insulin / metabolism*
  • Insulin / therapeutic use
  • Insulin Resistance
  • Memory Disorders / drug therapy
  • Memory Disorders / genetics
  • Memory Disorders / metabolism*
  • Memory Disorders / psychology
  • Memory* / drug effects
  • Mice, Mutant Strains
  • Phenotype
  • Signal Transduction

Substances

  • Insulin