Nucleophilic 1,1-Difluoroethylation with Fluorinated Phosphonium Salt

Zuyong Deng; Can Liu; Xian-Liang Zeng; Jin-Hong Lin; Ji-Chang Xiao

doi:10.1021/acs.joc.6b02723

Nucleophilic 1,1-Difluoroethylation with Fluorinated Phosphonium Salt

J Org Chem. 2016 Dec 16;81(24):12084-12090. doi: 10.1021/acs.joc.6b02723. Epub 2016 Dec 7.

Authors

Zuyong Deng¹, Can Liu^{1

2}, Xian-Liang Zeng¹, Jin-Hong Lin¹, Ji-Chang Xiao¹

Affiliations

¹ Key Laboratory of Organofluorine Chemistry, Shanghai Institute Of Organic Chmistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
² School of Chemistry and Chemical Engineering, University of South China , Hengyang 421001, P. R. China.

PMID: 27978722
DOI: 10.1021/acs.joc.6b02723

Abstract

The fluorinated phosphonium salt (Ph₃P⁺CF₂CH₃ BF₄^-) was shown to act as a nucleophilic 1,1-difluoroethylation agent to enable difluoroethylation of aldehydes and imines.

Publication types

Research Support, Non-U.S. Gov't