Iron-Catalyzed 1,5-Enyne Cycloisomerization via 5-Endo-Dig Cyclization for the Synthesis of 3-(Inden-1-yl)indole Derivatives

Swapnadeep Jalal; Kartick Paul; Umasish Jana

doi:10.1021/acs.orglett.6b03544

Iron-Catalyzed 1,5-Enyne Cycloisomerization via 5-Endo-Dig Cyclization for the Synthesis of 3-(Inden-1-yl)indole Derivatives

Org Lett. 2016 Dec 16;18(24):6512-6515. doi: 10.1021/acs.orglett.6b03544. Epub 2016 Dec 7.

Authors

Swapnadeep Jalal¹, Kartick Paul¹, Umasish Jana¹

Affiliation

¹ Department of Chemistry, Jadavpur University , Kolkata 700 032 West Bengal, India.

PMID: 27978665
DOI: 10.1021/acs.orglett.6b03544

Abstract

An Fe(OTf)₃-catalyzed 1,5-enyne cycloisomerization via 5-endo-dig cyclization is described for the synthesis of 3-(1-indenyl)indole derivatives. Since a variety of 1,5-enynes are readily accessible via Heck-Suzuki coupling, this strategy provides a rapid and easy access to a wide range of highly substituted 3-(1-indenyl)indoles in good yields.

Publication types

Research Support, Non-U.S. Gov't