Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters

Srestha Basu; Amaresh Kumar Sahoo; Anumita Paul; Arun Chattopadhyay

doi:10.1038/srep39005

Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters

Sci Rep. 2016 Dec 15:6:39005. doi: 10.1038/srep39005.

Authors

Srestha Basu¹, Amaresh Kumar Sahoo², Anumita Paul¹, Arun Chattopadhyay^{1

2}

Affiliations

¹ Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
² Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India.

Abstract

Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu²⁺ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu²⁺ added, thereby facilitating the detection of the desired concentration range of bilirubin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bilirubin / analysis*
Copper / chemistry*
Dermatoglyphics*
Female
Gold / chemistry*
Humans
Jaundice / diagnosis*
Male
Metal Nanoparticles / chemistry*
Point-of-Care Systems*

Substances

Gold
Copper
Bilirubin