Investigating Power Density and the Degree of Nonlinearity in Intrinsic Components of Anesthesia EEG by the Hilbert-Huang Transform: An Example Using Ketamine and Alfentanil

PLoS One. 2016 Dec 14;11(12):e0168108. doi: 10.1371/journal.pone.0168108. eCollection 2016.

Abstract

Empirical mode decomposition (EMD) is an adaptive filter bank for processing nonlinear and non-stationary signals, such as electroencephalographic (EEG) signals. EMD works well to decompose a time series into a set of intrinsic mode functions with specific frequency bands. An IMF therefore represents an intrinsic component on its correspondingly intrinsic frequency band. The word of 'intrinsic' means the frequency is totally adaptive to the nature of a signal. In this study, power density and nonlinearity are two critical parameters for characterizing the amplitude and frequency modulations in IMFs. In this study, a nonlinearity level is quantified using degree of waveform distortion (DWD), which represents the characteristic of waveform distortion as an assessment of the intra-wave modulation of an IMF. In the application of anesthesia EEG analysis, the assessments of power density and DWD for a set of IMFs represent dynamic responses in EEG caused by two different anesthesia agents, Ketamine and Alfentanil, on different frequency bands. Ketamine causes the increase of power density and the decrease of nonlinearity on γ-band neuronal oscillation, which cannot be found EEG responses of group B using Alfentanil. Both agents cause an increase of power density and a decrease of nonlinearity on β-band neuronal oscillation accompany with a loss of consciousness. Moreover, anesthesia agents cause the decreases of power density and nonlinearity (i.e. DWD) for the low-frequency IMFs.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Alfentanil / administration & dosage
  • Alfentanil / chemistry*
  • Algorithms
  • Anesthesia / methods*
  • Anesthesiology
  • Databases, Factual
  • Electroencephalography*
  • Humans
  • Ketamine / administration & dosage
  • Ketamine / chemistry*
  • Monitoring, Intraoperative / methods
  • Neurons / physiology
  • Nonlinear Dynamics
  • Oscillometry
  • Oximetry
  • Reproducibility of Results
  • Risk
  • Signal Processing, Computer-Assisted
  • Surgical Procedures, Operative

Substances

  • Alfentanil
  • Ketamine

Grants and funding

Authors wish to thank the support from Ministry of Science and Technology (Taiwan, R.O.C), Grant No MOST 103-2911- I-008- 001, and Office of Naval Research, Grand No N62909-15-1-N128. In addition, authors appreciate the support from National Taiwan University Hospital with Grant No.105-N3341.