The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.
Keywords: adiponectin; cholesterol; fatty liver; free fatty acids; ghrelin; glucagon; glucagon-like peptide 1; insulin; insulin resistance; irisin; leptin; selenoprotein P.