Abstract
Three new benzolactones (1-3), together with four known ones (4-7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1-3 showed obvious anti-TMV activities with inhibition rates of 26.9, 30.2, and 28.4%, which were at the same grade as positive control. Compounds 1-3 also showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 32.1-7.6 μM.
Keywords:
Lamiaceae; Lavandula angustifolia; anti-tobacco mosaic virus (TMV) activities; benzolactones; cytotoxic activities.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology*
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Furocoumarins / chemistry
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Furocoumarins / isolation & purification*
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Furocoumarins / pharmacology*
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Humans
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology*
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Lavandula / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Tobacco Mosaic Virus / drug effects
Substances
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4-hydroxy-6-(2-oxopropyl)isobenzofuran-1(3H)-one
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4-hydroxymethyl-6-(2-oxopropyl)-isobenzofuran-1(3H)-one
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89-dihydro-77-dimethyl-1H-furo(34-f)chromen-3(7H)-one
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Antiviral Agents
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Benzofurans
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Drugs, Chinese Herbal
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Furocoumarins
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Lactones