A Novel Link between Inflammation and Cancer

Yenkel Grinberg-Bleyer; Sankar Ghosh

doi:10.1016/j.ccell.2016.11.013

A Novel Link between Inflammation and Cancer

Cancer Cell. 2016 Dec 12;30(6):829-830. doi: 10.1016/j.ccell.2016.11.013.

Authors

Yenkel Grinberg-Bleyer¹, Sankar Ghosh²

Affiliations

¹ Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
² Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: sg2715@cumc.columbia.edu.

PMID: 27960080
DOI: 10.1016/j.ccell.2016.11.013

Abstract

Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilization and immune suppression in tumors.

MeSH terms

B7-H1 Antigen / metabolism*
COP9 Signalosome Complex
Cell Cycle Checkpoints
Gene Expression Regulation, Neoplastic
Humans
Immunity, Innate
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism*
NF-kappa B / metabolism
Neoplasms / genetics
Neoplasms / immunology*
Peptide Hydrolases / genetics
Peptide Hydrolases / metabolism*

Substances

B7-H1 Antigen
CD274 protein, human
Intracellular Signaling Peptides and Proteins
NF-kappa B
Peptide Hydrolases
COPS5 protein, human
COP9 Signalosome Complex