Liver Cancer Checks in When Bile Acid Clocks Out

Ting Fu; Xuan Zhao; Ronald M Evans

doi:10.1016/j.ccell.2016.11.012

Liver Cancer Checks in When Bile Acid Clocks Out

Cancer Cell. 2016 Dec 12;30(6):827-828. doi: 10.1016/j.ccell.2016.11.012.

Authors

Ting Fu¹, Xuan Zhao¹, Ronald M Evans²

Affiliations

¹ Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.

Abstract

In this issue of Cancer Cell, Kettner et al. identify the disruption of normal circadian rhythmicity as an independent risk factor for hepatocellular carcinoma (HCC) in experimental animals and reveal opposing roles for the nuclear receptors FXR and CAR in disease progression from non-alcoholic fatty liver disease (NAFLD) to HCC.

MeSH terms

Animals
Bile Acids and Salts / metabolism*
Carcinoma, Hepatocellular / epidemiology*
Circadian Rhythm
Disease Progression
Humans
Incidence
Liver Neoplasms / epidemiology*
Non-alcoholic Fatty Liver Disease / complications*
Non-alcoholic Fatty Liver Disease / metabolism
Risk Factors

Substances

Bile Acids and Salts

Abstract

MeSH terms

Substances

Grants and funding