New Synthesis of Gold- and Silver-Based Nano-Tetracycline Composites

Jamila Djafari; Catarina Marinho; Tiago Santos; Gilberto Igrejas; Carmen Torres; José Luis Capelo; Patricia Poeta; Carlos Lodeiro; Javier Fernández-Lodeiro

doi:10.1002/open.201600016

New Synthesis of Gold- and Silver-Based Nano-Tetracycline Composites

ChemistryOpen. 2016 Jun 3;5(3):206-212. doi: 10.1002/open.201600016. eCollection 2016 Jun.

Authors

Jamila Djafari¹, Catarina Marinho², Tiago Santos², Gilberto Igrejas³, Carmen Torres⁴, José Luis Capelo¹, Patricia Poeta⁵, Carlos Lodeiro¹, Javier Fernández-Lodeiro¹

Affiliations

¹ BIOSCOPE Group UCIBIO@REQUIMTE Chemistry Department, Faculty of Science and Technology University NOVA of Lisbon 2829-516 Monte da Caparica Portugal; ProteoMass Scientific Society Faculty of Sciences and Technology University NOVA of Lisbon Madan Parque. Building VI. Office 232829-516 Monte da Caparica Portugal.
² Functional Genomics and Proteomics Unit Department of Genetics and Biotechnology University of Trás-os-Montes and Alto Douro 5000-801 Vila Real Portugal; Veterinary Science Department University of Trás-os-Montes and Alto Douro 5000-801 Vila Real Portugal; UCIBIO@REQUIMTE Chemistry Department Faculty of Science and Technology University NOVA of Lisbon 2829-516 Monte da Caparica Portugal.
³ Functional Genomics and Proteomics Unit Department of Genetics and Biotechnology University of Trás-os-Montes and Alto Douro 5000-801 Vila Real Portugal; UCIBIO@REQUIMTE Chemistry Department Faculty of Science and Technology University NOVA of Lisbon 2829-516 Monte da Caparica Portugal.
⁴ Department of Food and Agriculture, Biochemistry and Molecular Biology University of La Rioja (UR) 26006 Logroño Spain.
⁵ Veterinary Science Department University of Trás-os-Montes and Alto Douro 5000-801 Vila Real Portugal; UCIBIO@REQUIMTE Chemistry Department Faculty of Science and Technology University NOVA of Lisbon 2829-516 Monte da Caparica Portugal.

Abstract

A new synthetic methodology of water-soluble gold and silver nanoparticles (AuNPs@TC and AgNPs@TC), using the antibiotic tetracycline (TC) as co-reducing and stabilizing agent, is reported. Both colloids exhibit high water stability. The average sizes obtained were 25±10 and 15±5 nm, respectively. Both composites were tested against TC-resistant bacteria, presenting an increasing antibacterial effect in the case of AgNPs@TC. The sensing towards metal ions was also explored. An interesting and reversible affinity of AuNPs@TC towards Al^III cations in an aqueous system was also observed.

Keywords: aluminum detection; antimicrobial studies; gold and silver nanoparticles; nanoantibiotics; nanochemical sensor.