Surveillance of patients with hereditary gastrointestinal cancer syndromes

Leticia Moreira; Antoni Castells

doi:10.1016/j.bpg.2016.10.004

Surveillance of patients with hereditary gastrointestinal cancer syndromes

Best Pract Res Clin Gastroenterol. 2016 Dec;30(6):923-935. doi: 10.1016/j.bpg.2016.10.004. Epub 2016 Oct 21.

Authors

Leticia Moreira¹, Antoni Castells²

Affiliations

¹ Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Catalonia, Spain. Electronic address: lmoreira@clinic.cat.
² Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Catalonia, Spain. Electronic address: castells@clinic.cat.

PMID: 27938787
DOI: 10.1016/j.bpg.2016.10.004

Abstract

Gastrointestinal cancers are among the most frequent tumors. Although most cases are sporadic, up to 5-6% develops in the context of gastrointestinal hereditary syndromes. These entities have specific characteristics and often a germline mutation identified, thus allowing performing genetic counseling. This review summarizes the most common gastrointestinal hereditary syndromes, focusing on the surveillance recommendations.

Keywords: Colorectal cancer; Gastric cancer; Germline mutation; Hereditary cancer syndrome; Pancreatic cancer; Prevention; Surveillance.

Publication types

Review

MeSH terms

Colorectal Neoplasms / diagnosis*
Colorectal Neoplasms / genetics
Genetic Predisposition to Disease*
Germ-Line Mutation*
Humans
Neoplastic Syndromes, Hereditary / diagnosis*
Neoplastic Syndromes, Hereditary / genetics
Pancreatic Neoplasms / diagnosis*
Pancreatic Neoplasms / genetics
Population Surveillance
Stomach Neoplasms / diagnosis*
Stomach Neoplasms / genetics