Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o-Hydroxyaryl Enaminones: Facile Access to 3-CF2 /CF3-Containing Chromones

Haoyue Xiang; Qinglan Zhao; Zhenyu Tang; Junan Xiao; Pengju Xia; Chaoming Wang; Chunhao Yang; Xiaoqing Chen; Hua Yang

doi:10.1021/acs.orglett.6b03441

Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o-Hydroxyaryl Enaminones: Facile Access to 3-CF₂ /CF₃-Containing Chromones

Org Lett. 2017 Jan 6;19(1):146-149. doi: 10.1021/acs.orglett.6b03441. Epub 2016 Dec 12.

Authors

Haoyue Xiang¹, Qinglan Zhao¹, Zhenyu Tang¹, Junan Xiao¹, Pengju Xia¹, Chaoming Wang¹, Chunhao Yang², Xiaoqing Chen¹, Hua Yang¹

Affiliations

¹ College of Chemistry and Chemical Engineering, Central South University , Changsha 410083, P. R. China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, P. R. China.

PMID: 27936762
DOI: 10.1021/acs.orglett.6b03441

Abstract

A practical and straightforward synthetic route to construct a variety of 3-CF₂/CF₃-containing chromones via photoredox catalysis was developed. This novel protocol features a visible-light-induced radical-triggered tandem cyclization.

Publication types

Research Support, Non-U.S. Gov't