New Furanone Derivatives and Alkaloids from the Co-Culture of Marine-Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum

Chem Biodivers. 2017 Mar;14(3). doi: 10.1002/cbdv.201600327.

Abstract

Six new compounds including two furanone derivatives sclerotiorumins A and B (1 and 2), one novel oxadiazin derivative sclerotiorumin C (3), one pyrrole derivative 1-(4-benzyl-1H-pyrrol-3-yl)ethanone (4), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin (5) and ferrineohydroxyaspergillin (6) were isolated from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4-oxadiazin-6-one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50 = 4.2 μm) and strong toxicity towards brine shrimp (LC50 = 6.1 μm), and oppositely increased the growth and biofilm formation of Staphylococcus aureus.

Keywords: Aspergillus sclerotiorum; 1,2,4-Oxadiazin-6-one; Complexes of neoaspergillic acid; Cytotoxic activities; Furanone derivatives.

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / toxicity
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Artemia / drug effects
  • Artemia / growth & development
  • Aspergillus / chemistry*
  • Aspergillus / growth & development
  • Aspergillus / metabolism
  • Biofilms / drug effects
  • Cell Survival / drug effects
  • Furans / chemistry*
  • Furans / isolation & purification
  • Furans / toxicity
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Penicillium / chemistry*
  • Penicillium / growth & development
  • Penicillium / metabolism
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / physiology
  • U937 Cells

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Furans

Associated data

  • GENBANK/JN851003.1
  • GENBANK/JN851004.1