Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide

Y Ueda; J M Chuang; L B Crast Jr; R A Partyka

doi:10.7164/antibiotics.42.1379

Synthesis and in vitro activity of new semi-synthetic coumermycin analogs: chemical modification at the C-3 amide

J Antibiot (Tokyo). 1989 Sep;42(9):1379-92. doi: 10.7164/antibiotics.42.1379.

Authors

Y Ueda¹, J M Chuang, L B Crast Jr, R A Partyka

Affiliation

¹ Antiinfective Chemistry Department, Bristol-Myers Company, Wallingford, CT 06492.

PMID: 2793593
DOI: 10.7164/antibiotics.42.1379

Abstract

Several new semi-synthetic coumermycin analogs, which carry a polar substituent at the C-3 amide moiety have been prepared. In vitro antibacterial activity of these new analogs against Gram-positive organisms, particularly methicillin-resistant strains of Staphylococci species has been described.

MeSH terms

Aminocoumarins
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology
Chemical Phenomena
Chemistry
Coumarins / chemical synthesis
Coumarins / pharmacology
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Aminocoumarins
Anti-Bacterial Agents
Coumarins
coumermycin