Exosomes, once thought to be biomarkers of a diseased state are now thought to be biologically active and some of the paracrine effects of stem cell therapy. While there is much excitement around their actions, there is also a growing need to better understand the role of cell source, exosome content, and exosome targeting in a quantitative manner. Better understanding of these variables and others, in a reproducible and comprehensive approach, could better inform future therapy.
Keywords: biomarkers; cardiovascular system; exosome; microRNA; systems biology.