Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

Giulia Torriani; Clara Galan-Navarro; Stefan Kunz

doi:10.1128/JVI.01902-16

Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

J Virol. 2017 Jan 31;91(4):e01902-16. doi: 10.1128/JVI.01902-16. Print 2017 Feb 15.

Authors

Giulia Torriani¹, Clara Galan-Navarro¹, Stefan Kunz²

Affiliations

¹ Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
² Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland Stefan.Kunz@chuv.ch.

Abstract

Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.

Keywords: Lassa fever; endocytosis; late endosome; receptor; viral entry.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dystroglycans / metabolism
Endocytosis
Endosomes / metabolism
Endosomes / virology
Host-Pathogen Interactions*
Humans
Lassa Fever / metabolism
Lassa Fever / virology*
Lassa virus / physiology*
Lysosomal-Associated Membrane Protein 1 / metabolism
Pinocytosis
Receptors, Virus / metabolism
Viral Tropism
Virus Internalization*

Substances

Lysosomal-Associated Membrane Protein 1
Receptors, Virus
Dystroglycans