Organocatalytic Coupling of CO2 with a Propargylic Alcohol: A Comprehensive Mechanistic Study

ChemSusChem. 2017 Mar 22;10(6):1241-1248. doi: 10.1002/cssc.201601524. Epub 2017 Jan 27.

Abstract

The metal-free coupling of a propargylic alcohol with CO2 catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in situ attenuated-total reflection IR (ATR-IR) spectroscopy and DFT calculations. Bicyclic guanidines, namely 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) are effective catalysts for the conversion of 2-methyl-3-butyn-2-ol to α-methylene cyclic carbonate and oxoalkyl acyclic carbonate under mild reaction conditions. The lower selectivity of TBD in comparison with MTBD towards the formation of α-methylene cyclic carbonate was elucidated from DFT calculations and is related to the bifunctional activity (base/H-bond donor) of TBD decreasing the Gibbs free energy of the reaction path for the formation of the acyclic carbonate.

Keywords: DFT calculations; bicyclic guanidine; carbon dioxide; organocatalysis; α-methylene carbonate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbon Dioxide / chemistry*
  • Catalysis
  • Kinetics
  • Models, Molecular
  • Molecular Conformation
  • Propanols / chemistry*
  • Quantum Theory

Substances

  • Alkynes
  • Propanols
  • Carbon Dioxide
  • propargyl alcohol