Neurobiochemical and psychological factors influencing the eating behaviors and attitudes in anorexia nervosa

J Physiol Biochem. 2017 May;73(2):297-305. doi: 10.1007/s13105-016-0540-2. Epub 2016 Dec 6.

Abstract

The aim of this study was to determine the characteristic features which contribute to inappropriate eating attitudes in people suffering from anorexia nervosa, based on an analysis of recent data. Factors influencing these attitudes have a genetic, neurobiological, biochemical, affective-motivational, cognitive, and behavioral background. Another important issue addressed in the paper is a description of the mechanism leading to continuous dietary restrictions. The altered activity of neurotransmitters modulating patients' moods after the consumption of food and a disturbed responsiveness to enterohormones enhance affective-motivational and cognitive aspects which, in turn, impede the improvement of eating behaviors. An understanding of the mechanisms behind the factors affecting the maintenance of inappropriate eating attitudes may contribute to greater effectiveness in the treatment of anorexia nervosa.

Keywords: Anorexia nervosa; Eating disorders; Nutritional attitudes; Nutritional behaviors.

Publication types

  • Review

MeSH terms

  • Animals
  • Anorexia Nervosa / etiology
  • Anorexia Nervosa / physiopathology*
  • Anorexia Nervosa / psychology
  • Anorexia Nervosa / therapy
  • Attitude to Health*
  • Cognitive Dysfunction / etiology
  • Cognitive Dysfunction / psychology
  • Cognitive Dysfunction / therapy
  • Combined Modality Therapy
  • Feeding Behavior* / psychology
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Models, Psychological*
  • Motivation
  • Nervous System Physiological Phenomena
  • Obsessive-Compulsive Disorder / physiopathology
  • Obsessive-Compulsive Disorder / psychology
  • Obsessive-Compulsive Disorder / therapy
  • Precision Medicine