Attempted suicide by ingestion of hair dye containing p-phenylenediamine: a case report

Ann Clin Biochem. 2017 Jul;54(4):507-510. doi: 10.1177/0004563216685117. Epub 2017 Feb 8.

Abstract

Para-phenylenediamine is widely used as a chemical in hair dyes and in combination with henna. This dye is used to paint the body for decorative reasons, to speed the processing time of henna and to intensify the results. Para-phenylenediamine is widely used in the Middle East, North Africa and India. Several reports have been published of the fatal ingestion of hair dye containing para-phenylenediamine. Here, we describe the case of a 14-year-old girl who ingested the compound but whose prompt treatment prevented her death. Ingestion of para-phenylenediamine produces a typical triad of angioneurotic oedema, rhabdomyolysis and acute tubular necrosis. Awareness of signs of these associated conditions in our patient, together with a comprehensive history, facilitated appropriate treatment to be instituted. We document the steps we took to enable her complete physical recovery.

Keywords: acute tubular necrosis; angioneurotic oedema; creatine kinase; henna; p-Phenylenediamine poisoning; rhabdomyolysis.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / pathology
  • Acute Kidney Injury / prevention & control*
  • Adolescent
  • Angioedema / chemically induced
  • Angioedema / diagnosis
  • Angioedema / pathology
  • Angioedema / prevention & control*
  • Chlorpheniramine / therapeutic use
  • Female
  • Fluid Therapy
  • Furosemide / therapeutic use
  • Hair Dyes / poisoning*
  • Humans
  • Hydrocortisone / analogs & derivatives
  • Hydrocortisone / therapeutic use
  • Naphthoquinones / poisoning
  • Phenylenediamines / poisoning*
  • Respiration, Artificial
  • Rhabdomyolysis / chemically induced
  • Rhabdomyolysis / diagnosis
  • Rhabdomyolysis / drug therapy*
  • Rhabdomyolysis / pathology
  • Suicide, Attempted / prevention & control*
  • Suicide, Attempted / psychology
  • Tracheostomy

Substances

  • Hair Dyes
  • Naphthoquinones
  • Phenylenediamines
  • hydrocortisone sodium phosphate
  • Chlorpheniramine
  • Furosemide
  • lawsone
  • 4-phenylenediamine
  • Hydrocortisone