Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma

J H Sherlynn Chan; Yen Leong Chua; Hong Yong Peh; Vojislav Jovanovic; Nicholas R J Gascoigne; W S Fred Wong; Fook Tim Chew; Brendon J Hanson; David M Kemeny; Paul A MacAry

doi:10.1016/j.jaci.2016.10.028

Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma

J Allergy Clin Immunol. 2017 May;139(5):1705-1708.e6. doi: 10.1016/j.jaci.2016.10.028. Epub 2016 Dec 5.

Authors

Affiliations

¹ Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore.
² Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³ Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.
⁴ Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore.
⁵ Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁶ Department of Biological Sciences, National University of Singapore, Singapore.
⁷ Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore.
⁸ Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore; Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, Singapore. Electronic address: paul_macary@nuhs.edu.sg.

PMID: 27923562
DOI: 10.1016/j.jaci.2016.10.028

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / immunology*
Animals
Antibodies, Monoclonal / genetics*
Antibodies, Monoclonal / therapeutic use
Antibodies, Neutralizing / genetics*
Antibodies, Neutralizing / therapeutic use
Asthma / immunology
Asthma / therapy*
Cells, Cultured
Humans
Hypersensitivity / immunology
Hypersensitivity / therapy*
Immunization
Immunodominant Epitopes / immunology*
Immunoglobulin E / metabolism
Immunoglobulin G / genetics*
Mice
Mice, Inbred C57BL
Mites / immunology
Models, Molecular
Peptide Library
Protein Engineering / methods*

Substances

Allergens
Antibodies, Monoclonal
Antibodies, Neutralizing
Immunodominant Epitopes
Immunoglobulin G
Peptide Library
allergen Blo t 5
Immunoglobulin E