Plazomicin Activity against 346 Extended-Spectrum-β-Lactamase/AmpC-Producing Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes

Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02454-16. doi: 10.1128/AAC.02454-16. Print 2017 Feb.

Abstract

The activity of plazomicin and clinically relevant aminoglycosides was tested against 346 extended-spectrum-β-lactamase/AmpC-producing Escherichia coli urinary isolates, and the results were correlated with the presence of aminoglycoside-modifying enzymes (AMEs). Data showed that plazomicin was very active against all ESBL/AmpC-producing E. coli urinary isolates. Its activity was not related to the AME genes studied.

Keywords: AMEs; ESBL; Escherichia coli; aminoglycosides; plazomicin.

MeSH terms

  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology
  • Escherichia coli / drug effects*
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Microbial Sensitivity Tests
  • Sisomicin / analogs & derivatives*
  • Sisomicin / pharmacology
  • Urinary Tract / microbiology
  • beta-Lactamases / metabolism*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • beta-Lactamases
  • plazomicin
  • Sisomicin