Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment

Yue Chen; Ming Xu; Jie Zhang; Juan Ma; Ming Gao; Zhihong Zhang; Yong Xu; Sijin Liu

doi:10.1002/adma.201604580

Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment

Adv Mater. 2017 Feb;29(6). doi: 10.1002/adma.201604580. Epub 2016 Dec 5.

Authors

Yue Chen^{1

2}, Ming Xu¹, Jie Zhang¹, Juan Ma¹, Ming Gao¹, Zhihong Zhang², Yong Xu², Sijin Liu¹

Affiliations

¹ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
² Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, 300211, China.

PMID: 27918113
DOI: 10.1002/adma.201604580

Abstract

Sublethal exposure of engineered nanomaterials (ENMs) induces the alteration of various cellular processes due to DNA methylation changes. DNA methylation variations represent a more sensitive fingerprint analysis of the direct and indirect effects that may be overlooked by traditional toxicity assays, and an understanding of the structure-activity relationship of DNA methylation upon ENMs would open a new path for their safer design.

Keywords: DNA methylation; adverse outcomes; engineered nanomaterials; nanosafety.