[Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report]

Hirohito Naruse; Norihiko Shimoyama; Tsugumi Satoh; Yoshiya Yamamoto; Kazuteru Hatanaka; Taiki Kudo; Masayoshi Ohno; Kazuharu Suzuki; Hajime Hirata; Marina Suzuki

doi:10.11405/nisshoshi.113.2057

[Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report]

Nihon Shokakibyo Gakkai Zasshi. 2016;113(12):2057-2066. doi: 10.11405/nisshoshi.113.2057.

[Article in Japanese]

Authors

Hirohito Naruse¹, Norihiko Shimoyama, Tsugumi Satoh, Yoshiya Yamamoto, Kazuteru Hatanaka, Taiki Kudo, Masayoshi Ohno, Kazuharu Suzuki, Hajime Hirata, Marina Suzuki

Affiliation

¹ Department of Gastroenterology, Hakodate Municipal Hospital.

PMID: 27916774
DOI: 10.11405/nisshoshi.113.2057

Abstract

A 73-year-old man with a hepatocellular carcinoma was admitted to our hospital. He suffered from recurrent severe hypoglycemia. An autopsy was performed after his death. Anti-insulin-like growth factor II (IGF-II) monoclonal antibody immunostaining of the hepatocellular carcinoma was positive. Western immunoblot analysis of the serum revealed highly elevated IGF-II. Therefore, we diagnosed this case as a non-islet cell tumor hypoglycemia caused by a big IGF-II-producing hepatocellular carcinoma.

Publication types

Case Reports
Review

MeSH terms

Aged
Autopsy
Carcinoma, Hepatocellular / complications*
Carcinoma, Hepatocellular / diagnostic imaging
Humans
Hypoglycemia / etiology*
Insulin-Like Growth Factor II / biosynthesis*
Liver Neoplasms / complications*
Liver Neoplasms / diagnostic imaging
Liver Neoplasms / pathology
Male
Tomography, X-Ray Computed

Substances

Insulin-Like Growth Factor II