PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance

Shingo Kajimura

doi:10.1016/j.stem.2016.11.010

PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance

Cell Stem Cell. 2016 Dec 1;19(6):675-676. doi: 10.1016/j.stem.2016.11.010.

Author

Shingo Kajimura¹

Affiliation

¹ UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: skajimura@diabetes.ucsf.edu.

Abstract

Adipocyte progenitor proliferation and self-renewal contribute to adipose tissue maintenance; however, the regulatory circuits of these processes are less understood. In this issue of Cell Stem Cell, Rivera-Gonzalez et al. (2016) show that PDGFA, which acts through PI3K-Akt pathways, plays a vital role in the proliferation and maintenance of adipocyte progenitors in dermal adipose tissues.

Publication types

Comment

MeSH terms

Adipocytes*
Adipose Tissue
Cell Differentiation
Cell Proliferation
Humans
Phosphatidylinositol 3-Kinases*
Stem Cells

Substances

Phosphatidylinositol 3-Kinases

Abstract

Publication types

MeSH terms

Substances

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